- Edyta Socha et al. Amino acid profiling as a method of discovering biomarkers for diagnosis of neurodegenerative diseases. Amino Acids. 2019 Mar;51(3):367-371.
Amino acids (AA) play very integral roles in the central nervous system as neurotransmitters, regulators of metabolism and neuromodulators. Research presented in this publication is focused on patients with Parkinson’s disease, Alzheimer disease, and elderly patients. In all analysed cases significant changes in the amino acid profile in patients comparing to healthy controls were observed. This study indicates potential of amino acid profiling as a method for diagnosis.
- Jesper F Havelund et al. Biomarker Research in Parkinson’s Disease Using Metabolite Profiling. Metabolites. 2017 Aug 11;7(3):42.
- Gennaro Pagano et al. Molecular Imaging of the Serotonergic System in Parkinson’s Disease. Int Rev Neurobiol. 2018;141:173-210.
- F J Jiménez-Jiménez et al. Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson’s disease: review and meta-analysis. Eur J Neurol . 2020 Nov;27(11):2336-2347.
- Monika Figura et al. Serum amino acid profile in patients with Parkinson’s disease. PLoS One. 2018 Jan 29;13(1):e0191670.
We conclude that a specific pattern of serum free amino acids including differences in concentrations of phenylalanine, arginine, alanine and threonine differs between early and advanced PD. Changes in glutamate and arginine concentrations may reflect neurodegenerative process of PD.
- Anna Picca et al. Circulating amino acid signature in older people with Parkinson’s disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study. Exp Gerontol. 2019 Dec;128:110766.
- Anna Wuolikainen et al. Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects. Mol Biosyst. 2016 Apr;12(4):1287-98.
- Daniel Stoessel et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson’s Disease. Front. Aging Neurosci., 05 March 2018
- Li Zhang et al. Reduced plasma taurine level in Parkinson’s disease: association with motor severity and levodopa treatment. Int J Neurosci. 2016;126(7):630-6.
Our study supports that taurine may play important roles in the pathophysiology of PD and the disturbances caused by chronic levodopa administration.
- Patrick L Heilman et al. Tryptophan Metabolites Are Associated with Symptoms and Nigral Pathology in Parkinson’s Disease. Mov Disord. 2020 Nov;35(11):2028-2037.
- Hirayama M et al. Serum Tyrosine-to-Phenylalanine Ratio is Low in Parkinson’s Disease. J Park. Dis 6, 423–431 (2016).