Cancer

Okamoto, N. Use of ‘AminoIndex Technology’ for Cancer Screening. Ningen Dock 26, 911–922 (2012).

Miyagi Y. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One. 2011;6(9):e24143.

These findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a relatively simple plasma assay and imposes a lower physical burden on subjects when compared to existing screening methods.

Haruo Mikamiet al. A multicentre clinical validation of Amino Index Cancer Screening (AICS). Sci Rep. 2019 Sep 25;9(1):13831.

AICS is a more useful method for evaluating the probability of cancer incidence than for predicting onset, suggesting that annual AICS should be recommended to detect any malignancy.

Atsushi Hiraoka et al. Easy clinical predictor for low BCAA to tyrosine ratio in chronic liver disease patients with hepatocellular carcinoma: Usefulness of ALBI score as nutritional prognostic marker. Cancer Med. 2021 Jun;10(11):3584-3592.

Miyagi E. Diagnostic Performance and Clinical Utility of Novel Gynecologic Cancer Screening Method Based on “AminoIndex Technology”. Official Journal of Japan Society of Ningen Dock Vol. 26 (2011) No. 5 Ningen Dock P 749-755

Fukutake N. A Novel Multivariate Index for Pancreatic Cancer Detection Based on the Plasma Free Amino Acid Profile. PLoS One. 2015 Jul 2;10(7):e0132223.

These findings suggest that the PFAA profile of PC was significantly different from that of HC. The PFAA index is a promising biomarker for screening and diagnosis of PC.

Ihata Y. Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker. Int J Clin Oncol. 2014 Apr;19(2):364-72.

The sensitivity and disease specificity of Plasma amino acid profile index for early-stage detection of endometrial cancer was superior to CA125. This novel plasma biomarker has the potential to become a diagnostic and screening marker for endometrial cancer.

Shingyoji M. The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer. BMC Cancer. 2013 Feb 15;13:77.

These findings suggest that PFAA profiling, which involves a relatively simple plasma assay and imposes a low physical burden on subjects, has great potential for improving early detection of lung cancer.

Yatabe J. Early detection of colon cancer by amino acid profiling using AminoIndex Technology: a case report. Diagn Pathol. 2013 Dec 10;8:203.

Zhao Q. Plasma and tissue free amino acid profiles and their concentration correlation in patients with lung cancer. Asia Pac J Clin Nutr. 2014;23(3):429-36.

PFAA profiles may reflect the status of cancer tissues, which may provide more information about the metabolic statuses and prognoses of patients with lung cancer.

Ma H. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy. World J Gastroenterol. 2014 Jul 14;20(26):8653-9.

Cascino A. Plasma amino acid imbalance in patients with lung and breast cancer. Anticancer Res. 1995; 15: 507–510.

Kubota A. Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors. Cancer. 1992; 69: 2343–2348.

Lai HS. Plasma free amino acid profile in cancer patients. Semin Cancer Biol.2005; 15: 267–276.
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Proenza AM. Breast and lung cancer are associated with a decrease in blood cell amino acid content. J Nutr Biochem . 2003;14: 133–138.

Maeda J. Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Cancer.2010; 10: 690.

Vissers YL. Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency? Am J Clin Nutr. 2005; 81: 1142–1146.