Obesity

Klaus J. Petzke. Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity. Int. J. Mol. Sci. 2014, 15, 1374-1391

Pasiakos SM. Effects of high-protein diets on fat free mass and muscle protein synthesis following weight loss: a randomized controlled trial. FASEB J. 2013 Sep;27(9):3837-47.

Mc Cormack SE. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr Obes. 2013 Feb;8(1):52-61.

Elevations in the concentrations of circulating BCAAs are significantly associated with obesity in children and adolescents, and may independently predict future insulin resistance.

D C D Hope, T M-M Tan. Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy. Peptides. 2023 Apr;162:170962.

Fei Xiao et al. Impacts of essential amino acids on energy balance. Mol Metab. 2022 Mar;57:101393.

Pekarovics S. et al. Stress-associated weight gain, fibromyalgia symptoms, cardiometabolic markers, and human growth hormone suppression respond to an amino acid supplement blend: Results of a prospective, cohort study. Front Endocrinol (Lausanne). 2023 Mar 14;14:1053692.

Sustained augmentation of IGF-1 with the test supplement may represent a novel method of improving clinical symptoms, including stress-related weight gain, in individuals with fibromyalgia and stress-associated low-normal hGH.

Marcus Moberg et al. Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C874-84.

In summary, EAA ingestion appears to stimulate translation initiation more effectively than the other supplements, although the results also suggest that this effect is primarily attributable to the BCAA.

Robert H Coker et al. Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals. Nutr J. 2012 Dec 11;11:105.

Qin LQ. the INTERMAP Cooperative Research Group. Higher branched‐chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults. J Nutr. 2011;141:249‐254

Xue Zhao et al. Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review. J Diabetes Res. 2016; 2016: 8160545.