Chronic Fatigue

  • Fukuda K. The Chronic Fatigue Syndrome Study: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994, 121:953–959.
  • Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev. 2000 Apr;5(2):93-108.
  • Yves Jammes et al. Understanding neuromuscular disorders in chronic fatigue syndrome F1000Res. 2019 Nov 28;8:F1000 Faculty Rev-2020.
  • Georgiades E. Chronic fatigue syndrome: new evidence for a central fatigue disorder. Clin Sci (Lond). 2003 Aug;105(2):213-8.

The significant differences observed in a number of key putative CNS 5-HT and dopaminergic modulators, coupled with the exacerbated perception of effort, provide further evidence for a potentially significant role for CNS mechanisms in the pathogenesis of CFS

  • Malhotra R. Tryptophan and Kynurenine Levels and Its Association with Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients. J Ren Nutr. 2017 Mar 30. pii: S1051-2276(17)30053-5.
  • Bralley JA.  Treatment of chronic fatigue syndrome with specific amino acid supplementation. Journal of Applied Nutrition. 1994, 46(3): (pp 74-78).
  • Evelina Georgiades et al. chronic fatigue syndrome: new evidence for a central fatigue disorder. Clin Sci (Lond). 2003 Aug;105(2):213-8.
  • Bahar Kavyani et al. Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle? Cell Mol Life Sci. 2022 Jul 11;79(8):412.
  • Masatoshi Yamashita. Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit. Int J Tryptophan Res. 2020 Jun 29;13:1178646920936279.
  • Newsholme EA.  Branched-chain amino acids and central fatigue. J Nutr. 2006;136(1 Suppl):274S-6S

Scientific Papers

Prediction/ Diagnosis /Treatment of Health Problems with Amino Acids: