Sleep Disorders:  insomnia/narcolepsy

  • Lisa Matricciani et al. Branched-chain amino acids and sleep: a population-derived study of Australian children aged 11-12 years and their parents. J Sleep Res. 2023 Feb 23;e13855.
  • Schneider-Helmert D.  Evaluation of L-tryptophan for treatment of insomnia: a review. Psychopharmacology  (Berl). 1986;89:1-7.
  • Korner E.  Sleep-inducing effect of L-tryptophane. Eur Neurol. 1986;25:75-81.
  • Makoto Bannai et al. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-8.
  • Ki-Bae Hong , Yooheon Park , Hyung Joo Suh. Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems. Nutr Res Pract. 2018 Jun;12(3):208-214.
  • Mouret J. Treatment of narcolepsy with L-tyrosine. Lancet. 1988 Dec 24-31;2(8626-8627):1458-9.

Patients with narcolepsy were treated with oral tyrosine. Within six months all were free from daytime sleep attacks and cataplexy.

  • Neri DF. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995;66:313-9

The results of this study also suggest that tyrosine is a relatively benign treatment at this dose. After further testing with other doses and timing of administration, tyrosine may prove useful in counteracting performance decrements during episodes of sustained work coupled with sleep loss.

  • J B Roufs. L-tyrosine in the treatment of narcolepsy . Med Hypotheses. 1990 Dec;33(4):269-73.
  • Suhyeon Kim et al. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.  Pharm Biol. 2019 Dec;57(1):65-73.

Scientific Papers

Prediction/ Diagnosis /Treatment of Health Problems with Amino Acids: